Depression is the leading cause of disability around the world, and for several decades, scientists have believed that low levels of the neurotransmitter serotonin was a major cause of depression. A new study in ACS Chemical Neuroscience questions that hypothesis, as the creation of serotonin-deficient mice did not lead to the presence of depression-like symptoms as expected. Researchers at Wayne State University found that although behavioral tests revealed that these serotonin-deficient mice were compulsive and aggressive, they did not show signs of depression. This indicates that the causes of depression need to be questioned more thoroughly so we can increase our understanding and so better therapies can be developed. Journal article: Mice Genetically Depleted of Brain Serotonin Do Not Display a Depression-like Behavioral Phenotype. ACS Chemical Neuroscience, 2014 Read more.
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