San Diego Union-Tribune Editorial cartoonist Steve Breen, in response to that old design, doesn’t seem to be a fan:
Hmph. Even God is a billboard vandal.
(For what it’s worth, the billboard’s message didn’t really require a response in the first place since it wasn’t asking for a debate. It was just a callout to the closeted atheists in the area.)
(Thanks to @SailorDad for the link!)