The governor of New York, Eliot Spitzer, a democrat who made a name for himself prosecuting white-collar shenanigans, was found to be a client of a high-price prostitution ring. His involvement was discovered when law enforcement officials saw suspicious wire transfers of funds that made them think the governor was laundering bribes!
As a rule, sexual misconduct dooms Republicans, but it usually is forgiven Democrats. This, however, looks to be an exception.