In the Book of Ezekiel, the eponymous prophet witnesses fantastic, even psychedelic visions: chariots in the sky, angels, the works. (Ezekiel 37 luridly recounts, for example, that the prophet sees a valley of bones that begin to reassemble themselves as he speaks.) But Ezekiel’s visions aren’t just odd. They’re profoundly meaningful, at least for the prophet. This combination of dreamlike oddness and paradoxical meaningfulness is one of the most pervasive qualities of religious – and entheogenic – experiences across traditions. Now, new neuroimaging research may help us understand one part of this picture: how psychedelic substances relax the normal patterns of connectivity in the brain, allowing for powerfully associative mental experiences.