You’ve felt it before: the embarrassed, self-conscious realization that you’ve just committed a major error, made a mistake when you should have been performing better. We all experience this unpleasant feeling. Measuring electrical activity in the brain, researchers call it “error-related negativity,” relating it particularly to a part of the midbrain called the anterior cingulate cortex. New research indicates that religiousness may reduce activity in this part of the brain, physiologically buffering people against their own mistakes. Most interestingly, the source of this effect may be the generation of meaning itself.