In 1901, American psychologist and philosopher William James gave a series of lectures that changed the study of religion forever. The lectures, later published as The Varieties of Religious Experience, took religious experiences seriously without considering whether or not they came from an objectively existing God. Regardless of their origins, James argued, religious experiences occur in every culture, and they are worthy of open-minded, careful study.

Religion scholar Jeffrey J. Kripal's Mutants and Mystics: Science Fiction, Superhero Comics, and the Paranormal begins with the same premise: human beings have paranormal experiences, and they deserve to be taken seriously. Kripal defines the paranormal as a type of mystical encounter, "a dramatic physical manifestation of the meaning and force of consciousness itself." As an example, he offers his own experience during a festival in India in 1989: Kripal felt the goddess Kali dancing upon his paralyzed body while he was flooded with sexual pleasure and occult information. Whereas religion used to be the primary repository for mystical ways of thinking, however, the decline of religious institutions and the rise of materialism have left a gap that is being filled by science fiction. Through research into the lives of speculative fiction writers and artists, Mutants and Mystics reveals the uncanny encounters that have inspired their art.

Mutants and Mystics builds from Kripal's earlier studies of Eastern and Western mysticism and the human potential movement. These historical and cross-cultural studies frame what he calls the "Super-Story," a set of narrative elements that recur over and over in American popular culture and provide a system of religious meaning for paranormal experiences. Comics by Alan Moore, Grant Morrison, Jack Kirby, and Otto Binder, as well as speculative works by Charles Fort, Philip K. Dick, Barry Windsor-Smith, Ray Palmer, Whitley Strieber, and others are contextualized within esoteric religious movements and alternative scientific models.

Kripal's Super-Story is thoroughly flavored with scientific language. In its narrative, humans have encounters with divine intelligences who come from far away (sometimes from outer space). Through contact with these beings or other means, humans discover a potent, often erotic energy within ourselves that can transform, save, or even destroy us. This energy is explored in the context of evolution, as we come to see ourselves as endlessly mutating, endlessly changing. We gradually become aware that we are in control of this creative process: humanity is self-creating, collectively crafting its own reality much as an author writes a story. Finally, we realize that the divine intelligences we encounter are not external after all, but a reflection of ourselves. As Kripal writes, "We can recognize that we are pulling our own strings, that the angels and aliens, gods and demons are us."

Kripal suggests that this is a story we can use. The Super-Story affirms the reality of the uncanny experiences that we and our loved ones may have, but it also expands our sense of what human beings can become. We are more than physical bodies, and we are more than what Western religion thinks of as "spirit"; rather, we are beings that are "Two-in-One," complex systems in which consciousness forms the body and the body forms consciousness.