Here is part of the statement issued by Holy See Press Office Director, Father Federico Lombardi SJ via Vatican Radio:
The terrible massacre that has taken place in Orlando, with its dreadfully high number of innocent victims, has caused in Pope Francis, and in all of us, the deepest feelings of horror and condemnation, of pain and turmoil before this new manifestation of homicidal folly and senseless hatred. Pope Francis joins the families of the victims and all of the injured in prayer and in compassion. Sharing in their indescribable suffering he entrusts them to the Lord so they may find comfort. We all hope that ways may be found, as soon as possible, to effectively identify and contrast the causes of such terrible and absurd violence which so deeply upsets the desire for peace of the American people and of the whole of humanity.